Mac Mania 1

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MacBinary | 1993-05-26 | 75.9 KB | [STAK/WILD]
open in:
MacOS 8.1 extracted |
Win98 extracted |
DOS extracted
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view as text

This file was processed as: MacBinary (archive/macBinary).

You can browse this item here: AIDS HTB
Confidence	Program	Detection	Match Type	Support
`100%`	dexvert	HyperCard Stack `(archive/hypercard)`	idMeta	Supported
`10%`	dexvert	MacBinary `(archive/macBinary)`	fallback	Supported
`100%`	file	MacBinary II, inited, Thu Aug 8 18:19:22 1991, modified Wed May 26 16:49:12 1993, creator HyperCard, type HyperCard stack, 35008 bytes "AIDS HTB" , at 0x8940 42397 bytes resource	default (weak)
`99%`	file	data	default
`74%`	TrID	Mac HyperCard stack (MacBinary)	default
`25%`	TrID	MacBinary 2	default (weak)
`100%`	siegfried	fmt/1762 MacBinary (II)	default
`100%`	lsar	MacBinary	default
id metadata
key	value
macFileType	`[STAK]`
macFileCreator	`[WILD]`
hex view
+--------+-------------------------+-------------------------+--------+--------+
|00000000| 00 08 41 49 44 53 20 48 | 54 42 00 00 00 00 00 00 |..AIDS H|TB......|
|00000010| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000020| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000030| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000040| 00 53 54 41 4b 57 49 4c | 44 01 00 00 00 00 00 00 |.STAKWIL|D.......|
|00000050| 00 00 00 00 00 88 c0 00 | 00 a5 9d a4 c7 73 ea a8 |........|.....s..|
|00000060| 29 88 48 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |).H.....|........|
|00000070| 00 00 00 00 00 00 00 00 | 00 00 81 81 e5 8c 00 00 |........|........|
|00000080| 00 00 08 00 53 54 41 4b | ff ff ff ff 00 00 00 00 |....STAK|........|
|00000090| 00 00 00 0a 00 00 88 c0 | 00 00 08 00 00 00 00 00 |........|........|
|000000a0| 00 00 00 00 00 00 00 01 | 00 00 0a e9 00 00 00 0a |........|........|
|000000b0| 00 00 0b ce 00 00 19 5a | 00 00 00 00 00 00 00 00 |.......Z|........|
|000000c0| 00 00 0f ed 00 00 00 00 | 00 05 00 00 10 00 00 00 |........|........|
|000000d0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000000e0| 02 10 80 00 02 10 80 00 | 02 01 80 00 02 10 80 00 |........|........|
|000000f0| 11 36 31 24 00 00 00 00 | 00 00 00 00 01 56 02 00 |.61$....|.....V..|
|00000100| 00 00 00 00 01 e0 02 80 | 00 00 00 00 00 00 00 00 |........|........|
|00000110| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000120| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000130| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000140| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000150| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000160| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000170| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000180| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000190| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000001a0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000001b0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000001c0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000001d0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000001e0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000001f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000200| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000210| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000220| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000230| 00 00 0d 52 00 00 0c d1 | 01 56 02 00 00 00 00 00 |...R....|.V......|
|00000240| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000250| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000260| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000270| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000280| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000290| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000002a0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000002b0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000002c0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000002d0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000002e0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000002f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000300| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000310| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000320| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000330| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000340| 00 00 00 00 00 00 00 00 | 80 00 00 00 08 00 00 00 |........|........|
|00000350| 88 00 22 00 88 00 22 00 | 88 88 22 22 88 88 22 22 |.."...".|..""..""|
|00000360| 88 aa 22 aa 88 aa 22 aa | cc aa 33 aa cc aa 33 aa |.."...".|..3...3.|
|00000370| 55 55 55 55 55 55 55 55 | ee bb bb ee ee bb bb ee |UUUUUUUU|........|
|00000380| ff bb ff ee ff bb ff ee | ff bb ff ff ff bb ff ff |........|........|
|00000390| 80 10 02 20 01 08 40 04 | ff ff ff ff ff ff ff ff |... ..@.|........|
|000003a0| 88 22 88 22 88 22 88 22 | 11 22 44 88 11 22 44 88 |."."."."|."D.."D.|
|000003b0| c4 80 0c 68 43 02 30 26 | b1 30 03 1b d8 c0 0c 8d |...hC.0&|.0......|
|000003c0| aa 00 aa 00 aa 00 aa 00 | 88 22 55 22 88 22 55 22 |........|."U"."U"|
|000003d0| 88 55 22 55 88 55 22 55 | 77 dd 77 dd 77 dd 77 dd |.U"U.U"U|w.w.w.w.|
|000003e0| 80 00 00 00 00 00 00 00 | aa 55 aa 55 aa 55 aa 55 |........|.U.U.U.U|
|000003f0| 03 84 48 30 0c 02 01 01 | 82 44 39 44 82 01 01 01 |..H0....|.D9D....|
|00000400| 88 14 22 41 88 41 22 14 | 80 80 41 3e 08 08 14 e3 |.."A.A".|..A>....|
|00000410| 22 04 8c 74 22 17 98 10 | be 80 88 08 eb 08 88 80 |"..t"...|........|
|00000420| 25 c8 32 89 64 24 4c 92 | a2 9c 41 be 2a c9 14 eb |%.2.d$L.|..A.*...|
|00000430| 40 a0 00 00 04 0a 00 00 | 80 40 20 00 02 04 08 00 |@.......|.@ .....|
|00000440| aa 00 80 00 88 00 80 00 | ff 80 80 80 80 80 80 80 |........|........|
|00000450| 08 1c 22 c1 80 01 02 04 | ff 80 80 80 ff 08 08 08 |..".....|........|
|00000460| f8 74 22 47 8f 17 22 71 | bf 00 bf bf b0 b0 b0 b0 |.t"G.."q|........|
|00000470| ff 7f be 5d a2 41 80 00 | fa f5 fa f5 a0 50 a0 50 |...].A..|.....P.P|
|00000480| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000490| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000004a0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000004b0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000004c0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000004d0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000004e0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000004f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000500| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000510| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000520| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000530| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000540| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000550| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000560| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000570| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000580| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000590| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000005a0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000005b0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000005c0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000005d0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000005e0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000005f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000600| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000610| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000620| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000630| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000640| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000650| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000660| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000670| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000680| 6f 6e 20 6f 70 65 6e 73 | 74 61 63 6b 0d 73 70 6c |on opens|tack.spl|
|00000690| 61 73 68 64 69 61 6c 6f | 67 20 31 30 30 30 2c 35 |ashdialo|g 1000,5|
|000006a0| 2c 74 72 75 65 0d 65 6e | 64 20 6f 70 65 6e 73 74 |,true.en|d openst|
|000006b0| 61 63 6b 0d 00 61 63 6b | 0d 00 61 74 20 75 6e 74 |ack..ack|..at unt|
|000006c0| 69 6c 20 6c 69 6e 65 43 | 6f 75 6e 74 20 3d 20 74 |il lineC|ount = t|
|000006d0| 68 65 20 6e 75 6d 62 65 | 72 20 6f 66 20 6c 69 6e |he numbe|r of lin|
|000006e0| 65 73 20 69 6e 20 77 68 | 20 2b 20 31 0d 69 66 20 |es in wh| + 1.if |
|000006f0| 6c 69 6e 65 20 6c 69 6e | 65 63 6f 75 6e 74 20 6f |line lin|ecount o|
|00000700| 66 20 77 68 20 3d 20 22 | 22 20 74 68 65 6e 0d 64 |f wh = "|" then.d|
|00000710| 65 6c 65 74 65 20 6c 69 | 6e 65 20 6c 69 6e 65 63 |elete li|ne linec|
|00000720| 6f 75 6e 74 20 6f 66 20 | 77 68 20 2d 2d 20 52 65 |ount of |wh -- Re|
|00000730| 6d 6f 76 65 20 42 6c 61 | 6e 6b 20 4c 69 6e 65 73 |move Bla|nk Lines|
|00000740| 0d 6e 65 78 74 20 72 65 | 70 65 61 74 0d 65 6e 64 |.next re|peat.end|
|00000750| 20 69 66 0d 69 66 20 6c | 69 6e 65 20 6c 69 6e 65 | if.if l|ine line|
|00000760| 63 6f 75 6e 74 20 6f 66 | 20 77 68 20 3e 20 6c 69 |count of| wh > li|
|00000770| 6e 65 20 28 6c 69 6e 65 | 63 6f 75 6e 74 2d 31 29 |ne (line|count-1)|
|00000780| 20 6f 66 20 77 68 20 74 | 68 65 6e 0d 61 64 64 20 | of wh t|hen.add |
|00000790| 6f 6e 65 20 74 6f 20 6c | 69 6e 65 63 6f 75 6e 74 |one to l|inecount|
|000007a0| 0d 6e 65 78 74 20 72 65 | 70 65 61 74 0d 65 6c 73 |.next re|peat.els|
|000007b0| 65 0d 2d 2d 20 46 69 6e | 64 20 6f 75 74 20 77 68 |e.-- Fin|d out wh|
|000007c0| 65 72 65 20 6c 69 6e 65 | 20 62 65 6c 6f 6e 67 73 |ere line| belongs|
|000007d0| 2c 20 70 75 74 20 69 74 | 20 74 68 65 72 65 2c 20 |, put it| there, |
|000007e0| 64 65 6c 65 74 65 20 6f | 6c 64 20 6c 69 6e 65 0d |delete o|ld line.|
|000007f0| 70 75 74 20 6c 69 6e 65 | 43 6f 75 6e 74 20 69 6e |put line|Count in|
|00000800| 74 6f 20 63 75 72 72 65 | 6e 6e 0d 72 65 70 65 61 |to curre|nn.repea|
|00000810| 74 20 77 69 74 68 20 62 | 61 63 6b 6c 69 6e 65 63 |t with b|acklinec|
|00000820| 6f 75 6e 74 20 3d 20 28 | 63 75 72 72 65 6e 6e 20 |ount = (|currenn |
|00000830| 2d 20 32 29 20 64 6f 77 | 6e 20 74 6f 20 30 0d 69 |- 2) dow|n to 0.i|
|00000840| 66 20 6c 69 6e 65 20 63 | 75 72 72 65 6e 6e 20 6f |f line c|urrenn o|
|00000850| 66 20 77 68 20 3e 20 c2 | 0d 6c 69 6e 65 20 62 61 |f wh > .|.line ba|
|00000860| 63 6b 6c 69 6e 65 63 6f | 75 6e 74 20 6f 66 20 77 |cklineco|unt of w|
|00000870| 68 20 74 68 65 6e 0d 69 | 66 20 62 61 63 6b 6c 69 |h then.i|f backli|
|00000880| 00 00 02 00 4d 41 53 54 | ff ff ff ff 00 00 00 00 |....MAST|........|
|00000890| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000008a0| 00 00 00 00 00 00 00 00 | 00 00 94 e9 00 01 7d ce |........|......}.|
|000008b0| 00 04 35 d1 00 04 38 52 | 00 01 7a d2 00 04 3b ed |..5...8R|..z...;.|
|000008c0| 00 01 8c f9 00 01 ea aa | 00 02 28 9e 00 02 54 a8 |........|..(...T.|
|000008d0| 00 02 99 be 00 02 b3 91 | 00 03 21 1a 00 03 e3 cb |........|..!.....|
|000008e0| 00 04 1b 70 00 00 50 5a | 00 00 54 89 00 00 00 00 |...p..PZ|..T.....|
|000008f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000900| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000910| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000920| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000930| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000940| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000950| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000960| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000970| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000980| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000990| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000009a0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000009b0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000009c0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000009d0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000009e0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000009f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a00| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a10| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a20| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a30| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a40| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a50| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a60| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a70| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000a80| 00 00 00 80 4c 49 53 54 | 00 00 19 5a 00 00 00 00 |....LIST|...Z....|
|00000a90| 00 00 00 01 00 00 08 00 | 00 00 00 0a 00 3c 00 02 |........|.....<..|
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|00000ab0| 00 00 1a 89 00 0a 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ac0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ad0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ae0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
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|00000b00| 00 00 08 00 50 41 47 45 | 00 00 1a 89 00 00 00 00 |....PAGE|........|
|00000b10| 00 00 19 5a c1 1e eb d1 | 00 00 0b ce 60 0c a9 11 |...Z....|....`...|
|00000b20| 04 18 0d d0 45 76 74 f2 | eb 14 0b 85 1f 0f 03 99 |....Evt.|........|
|00000b30| c5 ad 45 0c b3 23 22 46 | 5f 04 cd 80 a9 8c 3e 93 |..E..#"F|_.....>.|
|00000b40| f2 5e 2b 12 21 13 c8 6e | e2 15 03 0c 14 96 78 3c |.^+.!..n|......x<|
|00000b50| 2d b2 f1 09 00 00 10 f9 | 20 3f 7c df f3 ef 7f ef |-.......| ?|.....|
|00000b60| ff ff ef f7 ff ff ff 7f | f7 ff ef ff ff ff ff df |........|........|
|00000b70| ff ff ff ff ff fd 7b ff | ff df fb ff ff ff ff fe |......{.|........|
|00000b80| e7 7f df df ff f7 fb ff | ff ff ff bf ff ff ff ff |........|........|
|00000b90| 00 00 11 aa 20 7f ff ff | d7 fd df fe df f5 ff ff |.... ...|........|
|00000ba0| ff ff ff f7 3f ff ff bf | ef ff fd f5 ef 7f ff ff |....?...|........|
|00000bb0| fe ff ef ff ff ff fb ff | fe 77 db 9f f7 fe 7b ff |........|.w....{.|
|00000bc0| ff ff 7b b7 7f bf ff ff | ff ff ff ff 00 00 12 9e |..{.....|........|
|00000bd0| 20 7e fd 9f 8e e5 fe d7 | bf fc ea ff 6f db ff 3d | ~......|....o..=|
|00000be0| 7f 5f 8f 7b b1 7b ff 7b | b4 66 d3 2f 5f fd fb f3 |._.{.{.{|.f./_...|
|00000bf0| ee d6 ff bf f6 f7 f7 fe | c3 3f 7f fb df ff 63 35 |........|.?....c5|
|00000c00| 7f fb bf bb ff 9e fe ed | 00 00 13 a8 20 7e bf 3f |........|.... ~.?|
|00000c10| b6 ef fb 67 fd f7 6f f7 | fb ff ff df fe ff ff ff |...g..o.|........|
|00000c20| ff fd f7 bf ff ff 7e 7b | df ed dd fd ff ff fb bf |......~{|........|
|00000c30| fe ff bf ff 6b fe f9 ff | ff f7 ef ee ff fb ff f7 |....k...|........|
|00000c40| ff ff fd ff 00 00 14 be | 20 4e 7b 57 d4 ae 5d 6e |........| N{W..]n|
|00000c50| 9f a8 66 b7 7f 9b 4e 35 | d3 df cc 12 99 2f f3 5c |..f...N5|...../.\|
|00000c60| a4 72 6f bb 93 f7 6d 15 | ef ae b2 bf ad ed 1b 16 |.ro...m.|........|
|00000c70| fd 73 ba b8 db ba 2f ae | 4d 9f 5e 9c 57 1f df a9 |.s..../.|M.^.W...|
|00000c80| 00 00 15 91 20 7f fb ff | ff bd ff df ff f6 df f7 |.... ...|........|
|00000c90| ff f7 ff 7f ef ff df ff | df ff ff ff ff ff ee ff |........|........|
|00000ca0| df f7 df 7f ff df ff fd | ff ff ff ff ff fe ff ff |........|........|
|00000cb0| ff f7 fb ff ff fe fe ff | ff ff ff ff 00 00 16 1a |........|........|
|00000cc0| 20 7f ff ff ff ff ff ff | ff ff ff ff ff ff ff ff | .......|........|
|00000cd0| ff ff ff ff ff ff ff ff | ff ff ff ff ff ff ff f7 |........|........|
|00000ce0| ff ff ff ff ff ff ff ff | ff ff ff ff ff fb ff bf |........|........|
|00000cf0| ff ff ff ff ff ff ff ff | 00 00 17 cb 20 7f ff 9f |........|.... ...|
|00000d00| f7 ff 7f f7 ff f9 ff ff | fb ff ff fe ff ff ff ff |........|........|
|00000d10| f7 ff bf bf fd b7 77 7d | ff ef ff e7 ef df d3 ba |......w}|........|
|00000d20| af ff f6 df 7d 7e ff fa | ff f7 ef bf 7f ff fd bf |....}~..|........|
|00000d30| 77 ff ff fe 00 00 18 70 | 20 2f 0d 0b c1 59 8a 1c |w......p| /...Y..|
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|00000d50| 93 77 1e a2 c3 c8 7d 0a | fc 3d aa 98 27 f2 5c 85 |.w....}.|.=..'.\.|
|00000d60| ff 3e 75 dd 5e dc 49 3a | f7 3c 52 7f 05 f9 f2 08 |.>u.^.I:|.<R.....|
|00000d70| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000d80| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000d90| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000da0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000db0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000dc0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000dd0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000de0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000df0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e00| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e10| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e20| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e30| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e40| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e50| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e60| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e70| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e80| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000e90| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ea0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000eb0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ec0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ed0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00000ee0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
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|00003c30| 20 65 78 70 65 72 69 65 | 6e 63 65 20 73 6f 6d 65 | experie|nce some|
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|00003da0| 53 54 45 4d 0d 00 00 00 | 00 00 00 00 00 00 00 00 |STEM....|........|
|00003db0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
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|00003dd0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00003de0| 00 00 1a 89 00 00 0a e9 | 00 00 00 00 00 00 00 00 |........|........|
|00003df0| 00 02 00 00 07 6c 00 19 | 00 16 00 48 69 73 74 6f |.....l..|...Histo|
|00003e00| 72 69 63 61 6c 20 42 61 | 63 6b 67 72 6f 75 6e 64 |rical Ba|ckground|
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|000041c0| 69 72 65 64 20 69 6e 20 | 61 20 63 6f 6d 6d 6f 6e |ired in |a common|
|000041d0| 20 6d 61 6e 6e 65 72 2e | 20 54 68 65 6e 2c 20 69 | manner.| Then, i|
|000041e0| 6e 20 31 39 38 33 2c 20 | 61 20 54 2d 63 65 6c 6c |n 1983, |a T-cell|
|000041f0| 20 6c 79 6d 70 68 6f 74 | 72 6f 70 69 63 20 76 69 | lymphot|ropic vi|
|00004200| 72 75 73 20 77 61 73 20 | 73 65 70 61 72 61 74 65 |rus was |separate|
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|00004220| 20 52 6f 62 65 72 74 20 | 47 61 6c 6c 6f 20 61 74 | Robert |Gallo at|
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|00004250| 66 20 48 65 61 6c 74 68 | 20 61 6e 64 20 4c 75 63 |f Health| and Luc|
|00004260| 20 4d 6f 6e 74 61 67 6e | 69 65 72 20 61 74 20 46 | Montagn|ier at F|
|00004270| 72 61 6e 63 65 27 73 20 | 50 61 73 74 65 75 72 20 |rance's |Pasteur |
|00004280| 49 6e 73 74 69 74 75 74 | 65 2e 20 54 68 65 20 76 |Institut|e. The v|
|00004290| 69 72 75 73 20 77 61 73 | 20 61 74 20 66 69 72 73 |irus was| at firs|
|000042a0| 74 20 67 69 76 65 6e 20 | 76 61 72 69 6f 75 73 20 |t given |various |
|000042b0| 6e 61 6d 65 73 3a 20 68 | 75 6d 61 6e 20 6c 79 6d |names: h|uman lym|
|000042c0| 70 68 6f 74 72 6f 70 69 | 63 20 76 69 72 75 73 20 |photropi|c virus |
|000042d0| 28 48 54 4c 56 29 20 49 | 49 49 2c 20 6c 79 6d 70 |(HTLV) I|II, lymp|
|000042e0| 68 61 64 65 6e 6f 70 61 | 74 68 79 2d 61 73 73 6f |hadenopa|thy-asso|
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|00004340| 61 6c 6c 65 64 20 68 75 | 6d 61 6e 20 69 6d 6d 75 |alled hu|man immu|
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|00004390| 20 74 68 61 74 20 69 74 | 20 69 73 20 69 6e 64 65 | that it| is inde|
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|000043b0| 20 61 67 65 6e 74 20 66 | 6f 72 20 41 49 44 53 2e | agent f|or AIDS.|
|000043c0| 20 41 20 73 65 63 6f 6e | 64 20 73 74 72 61 69 6e | A secon|d strain|
|000043d0| 20 74 68 61 74 20 68 61 | 73 20 62 65 65 6e 20 69 | that ha|s been i|
|000043e0| 64 65 6e 74 69 66 69 65 | 64 2c 20 48 49 56 2d 32 |dentifie|d, HIV-2|
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|00004400| 6c 61 74 69 76 65 6c 79 | 20 72 61 72 65 20 6f 75 |latively| rare ou|
|00004410| 74 73 69 64 65 20 6f 66 | 20 41 66 72 69 63 61 2e |tside of| Africa.|
|00004420| 20 4c 69 74 74 6c 65 20 | 69 73 20 6b 6e 6f 77 6e | Little |is known|
|00004430| 20 61 62 6f 75 74 20 74 | 68 65 20 62 69 6f 6c 6f | about t|he biolo|
|00004440| 67 69 63 61 6c 20 61 6e | 64 20 67 65 6f 67 72 61 |gical an|d geogra|
|00004450| 70 68 69 63 61 6c 20 6f | 72 69 67 69 6e 73 20 6f |phical o|rigins o|
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|00004470| 79 2c 20 68 6f 77 65 76 | 65 72 2c 20 74 68 69 73 |y, howev|er, this|
|00004480| 20 69 73 20 74 68 65 20 | 66 69 72 73 74 20 74 69 | is the |first ti|
|00004490| 6d 65 20 69 6e 20 6d 6f | 64 65 72 6e 20 68 69 73 |me in mo|dern his|
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|000044b0| 72 75 73 20 68 61 73 20 | 73 70 72 65 61 64 20 77 |rus has |spread w|
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|000044e0| 64 20 76 69 72 75 73 65 | 73 20 68 61 76 65 20 62 |d viruse|s have b|
|000044f0| 65 65 6e 20 6f 62 73 65 | 72 76 65 64 20 69 6e 20 |een obse|rved in |
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|00004520| 61 69 6e 20 41 66 72 69 | 63 61 6e 20 6d 6f 6e 6b |ain Afri|can monk|
|00004530| 65 79 73 2c 20 62 75 74 | 20 74 68 65 73 65 20 64 |eys, but| these d|
|00004540| 6f 20 6e 6f 74 20 70 72 | 6f 64 75 63 65 20 64 69 |o not pr|oduce di|
|00004550| 73 65 61 73 65 20 69 6e | 20 68 75 6d 61 6e 73 2e |sease in| humans.|
|00004560| 0d 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00004570| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00004580| 00 00 05 80 43 41 52 44 | 00 00 12 9e 00 00 00 00 |....CARD|........|
|00004590| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000045a0| 00 00 1a 89 00 00 0a e9 | 00 00 00 00 00 00 00 00 |........|........|
|000045b0| 00 03 00 00 05 3a 00 19 | 00 18 00 54 68 65 20 4e |.....:..|...The N|
|000045c0| 61 74 75 72 65 20 6f 66 | 20 74 68 65 20 56 69 72 |ature of| the Vir|
|000045d0| 75 73 00 06 04 fc 80 16 | 00 00 00 01 00 0d 00 02 |us......|........|
|000045e0| 00 18 00 01 01 9d 00 02 | 01 a9 00 01 48 49 56 20 |........|....HIV |
|000045f0| 69 73 20 61 6e 20 52 4e | 41 20 52 45 54 52 4f 56 |is an RN|A RETROV|
|00004600| 49 52 55 53 2e 20 56 69 | 65 77 65 64 20 69 6e 20 |IRUS. Vi|ewed in |
|00004610| 61 6e 20 65 6c 65 63 74 | 72 6f 6e 20 6d 69 63 72 |an elect|ron micr|
|00004620| 6f 73 63 6f 70 65 2c 20 | 69 74 20 68 61 73 20 61 |oscope, |it has a|
|00004630| 20 64 65 6e 73 65 20 63 | 79 6c 69 6e 64 72 69 63 | dense c|ylindric|
|00004640| 61 6c 20 63 6f 72 65 20 | 74 68 61 74 20 65 6e 63 |al core |that enc|
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|00004670| 67 65 6e 65 74 69 63 20 | 6d 61 74 65 72 69 61 6c |genetic |material|
|00004680| 2e 20 41 20 73 70 68 65 | 72 69 63 61 6c 20 6f 75 |. A sphe|rical ou|
|00004690| 74 65 72 20 65 6e 76 65 | 6c 6f 70 65 20 73 75 72 |ter enve|lope sur|
|000046a0| 72 6f 75 6e 64 73 20 74 | 68 65 20 63 6f 72 65 2e |rounds t|he core.|
|000046b0| 20 0d 0d 20 4c 69 6b 65 | 20 61 6c 6c 20 72 65 74 | .. Like| all ret|
|000046c0| 72 6f 76 69 72 75 73 65 | 73 2c 20 48 49 56 20 70 |roviruse|s, HIV p|
|000046d0| 6f 73 73 65 73 73 65 73 | 20 61 20 73 70 65 63 69 |ossesses| a speci|
|000046e0| 61 6c 20 65 6e 7a 79 6d | 65 2c 20 63 61 6c 6c 65 |al enzym|e, calle|
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|00004700| 72 69 70 74 61 73 65 2c | 20 74 68 61 74 20 69 73 |riptase,| that is|
|00004710| 20 61 62 6c 65 20 74 6f | 20 6d 61 6b 65 20 61 20 | able to| make a |
|00004720| 44 4e 41 20 63 6f 70 79 | 20 6f 66 20 74 68 65 20 |DNA copy| of the |
|00004730| 76 69 72 61 6c 20 44 4e | 41 2e 20 54 68 69 73 20 |viral DN|A. This |
|00004740| 65 6e 61 62 6c 65 73 20 | 74 68 65 20 76 69 72 75 |enables |the viru|
|00004750| 73 20 74 6f 20 72 65 76 | 65 72 73 65 20 74 68 65 |s to rev|erse the|
|00004760| 20 6e 6f 72 6d 61 6c 20 | 66 6c 6f 77 20 6f 66 20 | normal |flow of |
|00004770| 67 65 6e 65 74 69 63 20 | 69 6e 66 6f 72 6d 61 74 |genetic |informat|
|00004780| 69 6f 6e 20 28 73 65 65 | 20 47 45 4e 45 54 49 43 |ion (see| GENETIC|
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|000049b0| 20 6f 6e 20 74 68 65 20 | 73 75 72 66 61 63 65 20 | on the |surface |
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|00004af0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00004b00| 00 00 08 a0 43 41 52 44 | 00 00 13 a8 00 00 00 00 |....CARD|........|
|00004b10| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00004b20| 00 00 1a 89 00 00 0a e9 | 00 00 00 00 00 00 00 00 |........|........|
|00004b30| 00 02 00 00 08 54 00 19 | 00 16 00 4d 6f 64 65 73 |.....T..|...Modes|
|00004b40| 20 6f 66 20 54 72 61 6e | 73 6d 69 73 73 69 6f 6e | of Tran|smission|
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|00004c30| 2c 20 74 68 61 74 20 48 | 49 56 20 69 73 20 74 72 |, that H|IV is tr|
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|00004c50| 68 72 6f 75 67 68 20 74 | 68 72 65 65 20 70 72 69 |hrough t|hree pri|
|00004c60| 6d 61 72 79 20 72 6f 75 | 74 65 73 3a 20 73 65 78 |mary rou|tes: sex|
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|00004ca0| 6e 20 69 6e 66 65 63 74 | 65 64 20 69 6e 64 69 76 |n infect|ed indiv|
|00004cb0| 69 64 75 61 6c 3b 20 6e | 6f 6e 64 69 67 65 73 74 |idual; n|ondigest|
|00004cc0| 69 76 65 20 65 78 70 6f | 73 75 72 65 20 74 6f 20 |ive expo|sure to |
|00004cd0| 69 6e 66 65 63 74 65 64 | 20 62 6c 6f 6f 64 20 6f |infected| blood o|
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|00004db0| 75 61 6c 20 6d 65 6e 20 | 61 63 63 6f 75 6e 74 69 |ual men |accounti|
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|00004dd0| 70 65 72 63 65 6e 74 20 | 6f 66 20 74 68 65 73 65 |percent |of these|
|00004de0| 20 63 61 73 65 73 2e 20 | 48 65 74 65 72 6f 73 65 | cases. |Heterose|
|00004df0| 78 75 61 6c 20 74 72 61 | 6e 73 6d 69 73 73 69 6f |xual tra|nsmissio|
|00004e00| 6e 20 69 6e 20 74 68 65 | 20 55 6e 69 74 65 64 20 |n in the| United |
|00004e10| 53 74 61 74 65 73 20 61 | 63 63 6f 75 6e 74 73 20 |States a|ccounts |
|00004e20| 66 6f 72 20 6f 6e 6c 79 | 20 61 62 6f 75 74 20 35 |for only| about 5|
|00004e30| 20 70 65 72 63 65 6e 74 | 20 6f 66 20 63 61 73 65 | percent| of case|
|00004e40| 73 2e 20 41 62 6f 75 74 | 20 32 31 20 70 65 72 63 |s. About| 21 perc|
|00004e50| 65 6e 74 20 6f 66 20 41 | 49 44 53 20 63 61 73 65 |ent of A|IDS case|
|00004e60| 73 20 61 72 65 20 63 61 | 75 73 65 64 20 62 79 20 |s are ca|used by |
|00004e70| 69 6e 74 72 61 76 65 6e | 6f 75 73 20 64 72 75 67 |intraven|ous drug|
|00004e80| 20 61 62 75 73 65 72 73 | 20 65 78 70 6f 73 65 64 | abusers| exposed|
|00004e90| 20 74 6f 20 48 49 56 2d | 69 6e 66 65 63 74 65 64 | to HIV-|infected|
|00004ea0| 20 62 6c 6f 6f 64 20 74 | 68 72 6f 75 67 68 20 74 | blood t|hrough t|
|00004eb0| 68 65 20 73 68 61 72 69 | 6e 67 20 6f 66 20 6e 65 |he shari|ng of ne|
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|00004ee0| 73 63 72 65 65 6e 69 6e | 67 20 62 6c 6f 6f 64 20 |screenin|g blood |
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|00004f10| 6c 6f 6f 64 20 61 6e 64 | 20 70 6c 61 73 6d 61 20 |lood and| plasma |
|00004f20| 66 6f 72 20 48 49 56 20 | 61 6e 74 69 62 6f 64 69 |for HIV |antibodi|
|00004f30| 65 73 20 68 61 76 65 20 | 72 65 64 75 63 65 64 20 |es have |reduced |
|00004f40| 74 68 65 20 6e 75 6d 62 | 65 72 20 6f 66 20 63 75 |the numb|er of cu|
|00004f50| 6d 75 6c 61 74 69 76 65 | 20 63 61 73 65 73 20 64 |mulative| cases d|
|00004f60| 75 65 20 74 6f 20 74 72 | 61 6e 73 66 75 73 69 6f |ue to tr|ansfusio|
|00004f70| 6e 20 74 6f 20 61 62 6f | 75 74 20 31 20 70 65 72 |n to abo|ut 1 per|
|00004f80| 63 65 6e 74 2e 20 54 68 | 65 20 6e 75 6d 62 65 72 |cent. Th|e number|
|00004f90| 20 6f 66 20 6e 65 77 20 | 63 61 73 65 73 20 6f 66 | of new |cases of|
|00004fa0| 20 41 49 44 53 20 69 6e | 20 77 6f 6d 65 6e 20 6f | AIDS in| women o|
|00004fb0| 66 20 72 65 70 72 6f 64 | 75 63 74 69 76 65 20 61 |f reprod|uctive a|
|00004fc0| 67 65 20 69 73 20 69 6e | 63 72 65 61 73 69 6e 67 |ge is in|creasing|
|00004fd0| 20 61 74 20 61 6e 20 61 | 6c 61 72 6d 69 6e 67 20 | at an a|larming |
|00004fe0| 72 61 74 65 2e 20 46 72 | 6f 6d 20 31 39 38 37 20 |rate. Fr|om 1987 |
|00004ff0| 74 6f 20 31 39 38 38 20 | 74 68 65 20 64 65 61 74 |to 1988 |the deat|
|00005000| 68 20 72 61 74 65 20 64 | 75 65 20 74 6f 20 41 49 |h rate d|ue to AI|
|00005010| 44 53 20 69 6e 20 77 6f | 6d 65 6e 20 31 35 20 74 |DS in wo|men 15 t|
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|00005030| 65 20 69 6e 63 72 65 61 | 73 65 64 20 62 79 20 34 |e increa|sed by 4|
|00005040| 30 20 70 65 72 63 65 6e | 74 2e 20 54 68 69 73 20 |0 percen|t. This |
|00005050| 74 72 65 6e 64 20 66 6f | 72 65 63 61 73 74 73 20 |trend fo|recasts |
|00005060| 74 68 65 20 64 65 76 61 | 73 74 61 74 69 6e 67 20 |the deva|stating |
|00005070| 69 6d 70 61 63 74 20 41 | 49 44 53 20 77 69 6c 6c |impact A|IDS will|
|00005080| 20 68 61 76 65 20 6f 6e | 20 69 6e 66 61 6e 74 20 | have on| infant |
|00005090| 6d 6f 72 74 61 6c 69 74 | 79 2c 20 73 69 6e 63 65 |mortalit|y, since|
|000050a0| 20 6f 76 65 72 20 38 30 | 20 70 65 72 63 65 6e 74 | over 80| percent|
|000050b0| 20 6f 66 20 48 49 56 2d | 69 6e 66 65 63 74 65 64 | of HIV-|infected|
|000050c0| 20 63 68 69 6c 64 72 65 | 6e 20 75 6e 64 65 72 20 | childre|n under |
|000050d0| 61 67 65 20 31 33 20 61 | 63 71 75 69 72 65 64 20 |age 13 a|cquired |
|000050e0| 48 49 56 20 66 72 6f 6d | 20 74 68 65 69 72 20 69 |HIV from| their i|
|000050f0| 6e 66 65 63 74 65 64 20 | 6d 6f 74 68 65 72 73 2e |nfected |mothers.|
|00005100| 20 42 65 74 77 65 65 6e | 20 32 34 20 74 6f 20 33 | Between| 24 to 3|
|00005110| 33 20 70 65 72 63 65 6e | 74 20 6f 66 20 63 68 69 |3 percen|t of chi|
|00005120| 6c 64 72 65 6e 20 62 6f | 72 6e 20 74 6f 20 69 6e |ldren bo|rn to in|
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|00005150| 73 65 61 73 65 2e 20 0d | 0d 20 4e 6f 20 73 63 69 |sease. .|. No sci|
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|00005170| 20 73 75 70 70 6f 72 74 | 73 20 74 72 61 6e 73 6d | support|s transm|
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|000051a0| 6e 6f 6e 73 65 78 75 61 | 6c 20 63 6f 6e 64 75 63 |nonsexua|l conduc|
|000051b0| 74 2e 20 43 61 72 65 66 | 75 6c 20 73 74 75 64 69 |t. Caref|ul studi|
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|000051d0| 68 61 74 20 64 65 73 70 | 69 74 65 20 70 72 6f 6c |hat desp|ite prol|
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|000051f0| 63 6f 6e 74 61 63 74 20 | 77 69 74 68 20 69 6e 66 |contact |with inf|
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|00005220| 73 20 68 61 76 65 20 6e | 6f 74 20 62 65 63 6f 6d |s have n|ot becom|
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|00005240| 70 74 20 74 68 72 6f 75 | 67 68 20 74 68 65 20 72 |pt throu|gh the r|
|00005250| 6f 75 74 65 73 20 64 65 | 73 63 72 69 62 65 64 20 |outes de|scribed |
|00005260| 61 62 6f 76 65 2e 20 53 | 69 6d 69 6c 61 72 6c 79 |above. S|imilarly|
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|00005280| 73 65 73 2c 20 70 68 79 | 73 69 63 69 61 6e 73 2c |ses, phy|sicians,|
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|000052a0| 68 20 70 72 6f 66 65 73 | 73 69 6f 6e 61 6c 20 63 |h profes|sional c|
|000052b0| 61 72 69 6e 67 20 66 6f | 72 20 41 49 44 53 20 70 |aring fo|r AIDS p|
|000052c0| 61 74 69 65 6e 74 73 20 | 68 61 76 65 20 72 65 76 |atients |have rev|
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|000052f0| 77 61 73 20 74 72 61 6e | 73 6d 69 74 74 65 64 20 |was tran|smitted |
|00005300| 74 68 72 6f 75 67 68 20 | 72 6f 75 74 69 6e 65 20 |through |routine |
|00005310| 63 6f 6e 74 61 63 74 73 | 2e 20 49 6e 20 61 64 64 |contacts|. In add|
|00005320| 69 74 69 6f 6e 2c 20 63 | 6c 61 69 6d 73 20 6f 66 |ition, c|laims of|
|00005330| 20 74 72 61 6e 73 6d 69 | 73 73 69 6f 6e 20 62 79 | transmi|ssion by|
|00005340| 20 69 6e 73 65 63 74 73 | 20 68 61 76 65 20 62 65 | insects| have be|
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|00005360| 20 6c 61 62 6f 72 61 74 | 6f 72 79 20 61 6e 64 20 | laborat|ory and |
|00005370| 65 70 69 64 65 6d 69 6f | 6c 6f 67 69 63 61 6c 20 |epidemio|logical |
|00005380| 73 74 75 64 69 65 73 2e | 0d 00 00 00 00 00 00 00 |studies.|........|
|00005390| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000053a0| 00 00 03 40 43 41 52 44 | 00 00 14 be 00 00 00 00 |...@CARD|........|
|000053b0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|000053c0| 00 00 1a 89 00 00 0a e9 | 00 00 00 00 00 00 00 00 |........|........|
|000053d0| 00 02 00 00 03 08 00 19 | 00 0f 00 43 6c 69 6e 69 |........|...Clini|
|000053e0| 63 61 6c 20 53 69 67 6e | 73 00 00 06 02 ef 00 46 |cal Sign|s......F|
|000053f0| 6f 6c 6c 6f 77 69 6e 67 | 20 69 6e 66 65 63 74 69 |ollowing| infecti|
|00005400| 6f 6e 20 77 69 74 68 20 | 48 49 56 2c 20 61 6e 20 |on with |HIV, an |
|00005410| 69 6e 64 69 76 69 64 75 | 61 6c 20 6d 61 79 20 73 |individu|al may s|
|00005420| 68 6f 77 20 6e 6f 20 73 | 79 6d 70 74 6f 6d 73 20 |how no s|ymptoms |
|00005430| 61 74 20 61 6c 6c 2c 20 | 6f 72 20 6d 61 79 20 64 |at all, |or may d|
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|00005450| 62 75 74 20 74 72 61 6e | 73 69 65 6e 74 20 6d 6f |but tran|sient mo|
|00005460| 6e 6f 6e 75 63 6c 65 6f | 73 69 73 2d 6c 69 6b 65 |nonucleo|sis-like|
|00005470| 20 69 6c 6c 6e 65 73 73 | 2e 20 54 68 65 20 70 65 | illness|. The pe|
|00005480| 72 69 6f 64 20 62 65 74 | 77 65 65 6e 20 69 6e 69 |riod bet|ween ini|
|00005490| 74 69 61 6c 20 69 6e 66 | 65 63 74 69 6f 6e 20 61 |tial inf|ection a|
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|000054d0| 61 72 65 6e 74 6c 79 20 | 66 72 6f 6d 20 61 62 6f |arently |from abo|
|000054e0| 75 74 20 36 20 6d 6f 6e | 74 68 73 20 74 6f 20 31 |ut 6 mon|ths to 1|
|000054f0| 31 20 79 65 61 72 73 2e | 20 56 61 72 69 6f 75 73 |1 years.| Various|
|00005500| 20 65 73 74 69 6d 61 74 | 65 73 20 69 6e 64 69 63 | estimat|es indic|
|00005510| 61 74 65 20 74 68 61 74 | 20 73 6f 6d 65 77 68 65 |ate that| somewhe|
|00005520| 72 65 20 62 65 74 77 65 | 65 6e 20 32 36 20 74 6f |re betwe|en 26 to|
|00005530| 20 34 36 20 70 65 72 63 | 65 6e 74 20 6f 66 20 69 | 46 perc|ent of i|
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|00005550| 61 6c 73 20 77 69 6c 6c | 20 67 6f 20 6f 6e 20 74 |als will| go on t|
|00005560| 6f 20 64 65 76 65 6c 6f | 70 20 66 75 6c 6c 2d 62 |o develo|p full-b|
|00005570| 6c 6f 77 6e 20 41 49 44 | 53 20 77 69 74 68 69 6e |lown AID|S within|
|00005580| 20 61 20 6c 69 74 74 6c | 65 20 6d 6f 72 65 20 74 | a littl|e more t|
|00005590| 68 61 6e 20 37 20 79 65 | 61 72 73 20 66 6f 6c 6c |han 7 ye|ars foll|
|000055a0| 6f 77 69 6e 67 20 69 6e | 66 65 63 74 69 6f 6e 2e |owing in|fection.|
|000055b0| 20 57 68 69 6c 65 20 73 | 6f 6d 65 20 48 49 56 2d | While s|ome HIV-|
|000055c0| 69 6e 66 65 63 74 65 64 | 20 70 65 72 73 6f 6e 73 |infected| persons|
|000055d0| 20 6d 61 79 20 61 70 70 | 65 61 72 20 68 65 61 6c | may app|ear heal|
|000055e0| 74 68 79 2c 20 67 72 6f | 77 69 6e 67 20 65 76 69 |thy, gro|wing evi|
|000055f0| 64 65 6e 63 65 20 73 75 | 67 67 65 73 74 73 20 74 |dence su|ggests t|
|00005600| 68 61 74 20 74 68 65 79 | 20 65 78 70 65 72 69 65 |hat they| experie|
|00005610| 6e 63 65 20 73 75 62 74 | 6c 65 20 62 75 74 20 69 |nce subt|le but i|
|00005620| 6d 70 6f 72 74 61 6e 74 | 20 64 65 66 65 63 74 73 |mportant| defects|
|00005630| 20 6f 66 20 69 6d 6d 75 | 6e 65 20 66 75 6e 63 74 | of immu|ne funct|
|00005640| 69 6f 6e 2e 20 4f 6e 63 | 65 20 61 20 64 69 61 67 |ion. Onc|e a diag|
|00005650| 6e 6f 73 69 73 20 6f 66 | 20 41 49 44 53 20 63 61 |nosis of| AIDS ca|
|00005660| 6e 20 63 6c 65 61 72 6c | 79 20 62 65 20 6d 61 64 |n clearl|y be mad|
|00005670| 65 2c 20 74 68 65 20 63 | 6c 69 6e 69 63 61 6c 20 |e, the c|linical |
|00005680| 63 6f 75 72 73 65 20 67 | 65 6e 65 72 61 6c 6c 79 |course g|enerally|
|00005690| 20 66 6f 6c 6c 6f 77 73 | 20 61 20 72 65 6c 65 6e | follows| a relen|
|000056a0| 74 6c 65 73 73 20 64 65 | 63 6c 69 6e 65 2c 20 77 |tless de|cline, w|
|000056b0| 69 74 68 20 64 65 61 74 | 68 20 6f 63 63 75 72 72 |ith deat|h occurr|
|000056c0| 69 6e 67 20 77 69 74 68 | 69 6e 20 6f 6e 65 20 74 |ing with|in one t|
|000056d0| 6f 20 74 77 6f 20 79 65 | 61 72 73 2e 0d 00 00 00 |o two ye|ars.....|
|000056e0| 00 00 0d c0 43 41 52 44 | 00 00 15 91 00 00 00 00 |....CARD|........|
|000056f0| 00 00 00 00 00 00 00 00 | 00 00 00 00 00 00 00 00 |........|........|
|00005700| 00 00 1a 89 00 00 0a e9 | 00 00 00 00 00 00 00 00 |........|........|
|00005710| 00 03 00 00 0d 7c 00 19 | 00 25 00 4f 70 70 6f 72 |.....|..|.%.Oppor|
|00005720| 74 75 6e 69 73 74 69 63 | 20 49 6e 66 65 63 74 69 |tunistic| Infecti|
|00005730| 6f 6e 73 20 61 6e 64 20 | 43 61 6e 63 65 72 73 00 |ons and |Cancers.|
|00005740| 00 06 0c b0 80 6e 00 00 | 00 01 00 e1 00 02 00 ea |.....n..|........|
|00005750| 00 01 01 82 00 02 01 8f | 00 01 01 c3 00 02 01 ce |........|........|
|00005760| 00 01 01 e6 00 02 01 f5 | 00 01 02 48 00 02 02 54 |........|...H...T|
|00005770| 00 01 02 9e 00 02 02 a4 | 00 01 03 22 00 02 03 29 |........|..."...)|
|00005780| 00 01 03 68 00 02 03 79 | 00 01 06 87 00 02 06 93 |...h...y|........|
|00005790| 00 01 06 99 00 02 06 a1 | 00 01 07 a4 00 02 07 aa |........|........|
|000057a0| 00 01 09 73 00 02 09 81 | 00 01 09 84 00 02 09 8d |...s....|........|
|000057b0| 00 01 42 65 63 61 75 73 | 65 20 74 68 65 20 54 34 |..Becaus|e the T4|
|000057c0| 20 63 65 6c 6c 20 69 73 | 20 69 6e 76 6f 6c 76 65 | cell is| involve|
|000057d0| 64 20 69 6e 20 61 6c 6d | 6f 73 74 20 61 6c 6c 20 |d in alm|ost all |
|000057e0| 69 6d 6d 75 6e 65 20 72 | 65 73 70 6f 6e 73 65 73 |immune r|esponses|
|000057f0| 2c 20 69 74 73 20 64 65 | 70 6c 65 74 69 6f 6e 20 |, its de|pletion |
|00005800| 72 65 6e 64 65 72 73 20 | 74 68 65 20 62 6f 64 79 |renders |the body|
|00005810| 20 68 69 67 68 6c 79 20 | 73 75 73 63 65 70 74 69 | highly |suscepti|
|00005820| 62 6c 65 20 74 6f 20 6f | 70 70 6f 72 74 75 6e 69 |ble to o|pportuni|
|00005830| 73 74 69 63 20 69 6e 66 | 65 63 74 69 6f 6e 73 20 |stic inf|ections |
|00005840| 61 6e 64 20 74 75 6d 6f | 72 6f 75 73 20 67 72 6f |and tumo|rous gro|
|00005850| 77 74 68 73 2e 20 54 68 | 65 20 6d 6f 73 74 20 70 |wths. Th|e most p|
|00005860| 72 65 64 6f 6d 69 6e 61 | 6e 74 20 61 6e 64 20 74 |redomina|nt and t|
|00005870| 68 72 65 61 74 65 6e 69 | 6e 67 20 69 73 20 50 6e |hreateni|ng is Pn|
|00005880| 65 75 6d 6f 63 79 73 74 | 69 63 20 63 61 72 69 6e |eumocyst|ic carin|
|00005890| 69 69 20 50 4e 45 55 4d | 4f 4e 49 41 2c 20 77 68 |ii PNEUM|ONIA, wh|
|000058a0| 69 63 68 20 69 73 20 66 | 72 65 71 75 65 6e 74 6c |ich is f|requentl|
|000058b0| 79 20 74 68 65 20 66 69 | 72 73 74 20 69 6e 66 65 |y the fi|rst infe|
|000058c0| 63 74 69 6f 6e 20 74 6f | 20 6f 63 63 75 72 20 61 |ction to| occur a|
|000058d0| 6e 64 20 69 73 20 74 68 | 65 20 6d 6f 73 74 20 63 |nd is th|e most c|
|000058e0| 6f 6d 6d 6f 6e 20 63 61 | 75 73 65 20 6f 66 20 64 |ommon ca|use of d|
|000058f0| 65 61 74 68 2e 20 4f 74 | 68 65 72 20 69 6e 66 65 |eath. Ot|her infe|
|00005900| 63 74 69 6f 6e 73 20 69 | 6e 63 6c 75 64 65 20 74 |ctions i|nclude t|
|00005910| 68 65 20 70 61 72 61 73 | 69 74 65 73 20 54 6f 78 |he paras|ites Tox|
|00005920| 6f 70 6c 61 73 6d 61 20 | 67 6f 6e 64 69 69 20 28 |oplasma |gondii (|
|00005930| 73 65 65 20 54 4f 58 4f | 50 4c 41 53 4d 4f 53 49 |see TOXO|PLASMOSI|
|00005940| 53 29 20 61 6e 64 20 43 | 72 79 70 74 6f 73 70 6f |S) and C|ryptospo|
|00005950| 72 69 64 69 6f 73 69 73 | 3b 20 66 75 6e 67 69 20 |ridiosis|; fungi |
|00005960| 73 75 63 68 20 61 73 20 | 43 61 6e 64 69 64 61 20 |such as |Candida |
|00005970| 28 73 65 65 20 43 41 4e | 44 49 44 49 41 53 49 53 |(see CAN|DIDIASIS|
|00005980| 29 20 61 6e 64 20 43 72 | 79 70 74 6f 63 6f 63 63 |) and Cr|yptococc|
|00005990| 75 73 20 28 73 65 65 20 | 46 55 4e 47 55 53 20 44 |us (see |FUNGUS D|
|000059a0| 49 53 45 41 53 45 53 29 | 3b 20 6d 79 63 6f 62 61 |ISEASES)|; mycoba|
|000059b0| 63 74 65 72 69 61 20 73 | 75 63 68 20 61 73 20 4d |cteria s|uch as M|
|000059c0| 79 63 6f 62 61 63 74 65 | 72 69 75 6d 20 61 76 69 |ycobacte|rium avi|
|000059d0| 75 6d 2c 20 69 6e 74 72 | 61 63 65 6c 6c 75 6c 61 |um, intr|acellula|
|000059e0| 72 65 2c 20 61 6e 64 20 | 74 75 62 65 72 63 75 6c |re, and |tubercul|
|000059f0| 6f 73 69 73 20 28 73 65 | 65 20 54 55 42 45 52 43 |osis (se|e TUBERC|
|00005a00| 55 4c 4f 53 49 53 29 3b | 20 61 6e 64 20 76 69 72 |ULOSIS);| and vir|
|00005a10| 75 73 65 73 20 73 75 63 | 68 20 61 73 20 63 79 74 |uses suc|h as cyt|
|00005a20| 6f 6d 65 67 61 6c 6f 76 | 69 72 75 73 20 61 6e 64 |omegalov|irus and|
|00005a30| 20 68 65 72 70 65 73 20 | 73 69 6d 70 6c 65 78 20 | herpes |simplex |
|00005a40| 61 6e 64 20 7a 6f 73 74 | 65 72 20 28 73 65 65 20 |and zost|er (see |
|00005a50| 48 45 52 50 45 53 29 2e | 20 49 6e 63 72 65 61 73 |HERPES).| Increas|
|00005a60| 65 64 20 73 75 73 63 65 | 70 74 69 62 69 6c 69 74 |ed susce|ptibilit|
|00005a70| 79 20 74 6f 20 62 61 63 | 74 65 72 69 61 6c 20 69 |y to bac|terial i|
|00005a80| 6e 66 65 63 74 69 6f 6e | 20 69 73 20 6e 6f 74 65 |nfection| is note|
|00005a90| 64 20 70 61 72 74 69 63 | 75 6c 61 72 6c 79 20 61 |d partic|ularly a|
|00005aa0| 6d 6f 6e 67 20 63 68 69 | 6c 64 72 65 6e 20 77 69 |mong chi|ldren wi|
|00005ab0| 74 68 20 41 49 44 53 2e | 20 4d 61 6e 79 20 41 49 |th AIDS.| Many AI|
|00005ac0| 44 53 20 70 61 74 69 65 | 6e 74 73 20 64 65 76 65 |DS patie|nts deve|
|00005ad0| 6c 6f 70 20 43 41 4e 43 | 45 52 53 2c 20 69 6e 63 |lop CANC|ERS, inc|
|00005ae0| 6c 75 64 69 6e 67 20 4b | 61 70 6f 73 69 27 73 20 |luding K|aposi's |
|00005af0| 73 61 72 63 6f 6d 61 20 | 28 4b 53 29 2c 20 6e 6f |sarcoma |(KS), no|
|00005b00| 6e 2d 48 6f 64 67 6b 69 | 6e 27 73 20 6c 79 6d 70 |n-Hodgki|n's lymp|
|00005b10| 68 6f 6d 61 2c 20 61 6e | 64 20 48 4f 44 47 4b 49 |homa, an|d HODGKI|
|00005b20| 4e 27 53 20 44 49 53 45 | 41 53 45 2e 20 4b 53 20 |N'S DISE|ASE. KS |
|00005b30| 6f 63 63 75 72 73 20 69 | 6e 20 70 61 74 69 65 6e |occurs i|n patien|
|00005b40| 74 73 20 77 68 6f 20 6d | 61 6e 69 66 65 73 74 20 |ts who m|anifest |
|00005b50| 68 61 72 64 6c 79 20 61 | 6e 79 20 65 76 69 64 65 |hardly a|ny evide|
|00005b60| 6e 63 65 20 6f 66 20 69 | 6d 6d 75 6e 6f 6c 6f 67 |nce of i|mmunolog|
|00005b70| 69 63 61 6c 20 69 6d 70 | 61 69 72 6d 65 6e 74 2c |ical imp|airment,|
|00005b80| 20 69 6e 64 69 63 61 74 | 69 6e 67 20 74 68 61 74 | indicat|ing that|
|00005b90| 20 6f 74 68 65 72 20 66 | 61 63 74 6f 72 73 20 6d | other f|actors m|
|00005ba0| 61 79 20 61 6c 73 6f 20 | 62 65 20 61 74 20 77 6f |ay also |be at wo|
|00005bb0| 72 6b 20 69 6e 20 74 68 | 65 20 64 65 76 65 6c 6f |rk in th|e develo|
|00005bc0| 70 6d 65 6e 74 20 6f 66 | 20 73 75 63 68 20 63 61 |pment of| such ca|
|00005bd0| 6e 63 65 72 73 2e 20 41 | 6d 6f 6e 67 20 74 68 65 |ncers. A|mong the|
|00005be0| 20 6e 6f 6e 2d 48 6f 64 | 67 6b 69 6e 27 73 20 6c | non-Hod|gkin's l|
|00005bf0| 79 6d 70 68 6f 6d 61 73 | 20 61 72 65 20 69 6d 6d |ymphomas| are imm|
|00005c00| 75 6e 6f 62 6c 61 73 74 | 69 63 20 61 6e 64 20 42 |unoblast|ic and B|
|00005c10| 75 72 6b 69 74 74 27 73 | 2d 74 79 70 65 20 6c 79 |urkitt's|-type ly|
|00005c20| 6d 70 68 6f 6d 61 73 20 | 61 73 20 77 65 6c 6c 20 |mphomas |as well |
|00005c30| 61 73 20 70 72 69 6d 61 | 72 79 20 62 72 61 69 6e |as prima|ry brain|
|00005c40| 20 6c 79 6d 70 68 6f 6d | 61 73 2e 20 54 68 65 73 | lymphom|as. Thes|
|00005c50| 65 20 74 75 6d 6f 72 73 | 20 74 65 6e 64 20 74 6f |e tumors| tend to|
|00005c60| 20 62 65 20 75 6e 75 73 | 75 61 6c 6c 79 20 61 67 | be unus|ually ag|
|00005c70| 67 72 65 73 73 69 76 65 | 20 61 6e 64 20 70 6f 6f |gressive| and poo|
|00005c80| 72 6c 79 20 72 65 73 70 | 6f 6e 73 69 76 65 20 74 |rly resp|onsive t|
|00005c90| 6f 20 63 68 65 6d 6f 74 | 68 65 72 61 70 68 79 2c |o chemot|heraphy,|
|00005ca0| 20 70 61 72 74 69 63 75 | 6c 61 72 6c 79 20 69 6e | particu|larly in|
|00005cb0| 20 41 49 44 53 20 70 61 | 74 69 65 6e 74 73 20 77 | AIDS pa|tients w|
|00005cc0| 68 6f 20 68 61 76 65 20 | 61 6c 72 65 61 64 79 20 |ho have |already |
|00005cd0| 65 78 70 65 72 69 65 6e | 63 65 64 20 6f 70 70 6f |experien|ced oppo|
|00005ce0| 72 74 75 6e 69 73 74 69 | 63 20 69 6e 66 65 63 74 |rtunisti|c infect|
|00005cf0| 69 6f 6e 73 2e 20 4f 74 | 68 65 72 20 48 49 56 2d |ions. Ot|her HIV-|
|00005d00| 52 65 6c 61 74 65 64 20 | 44 69 73 6f 72 64 65 72 |Related |Disorder|
|00005d10| 73 20 61 6e 64 20 43 6f | 66 61 63 74 6f 72 73 20 |s and Co|factors |
|00005d20| 0d 0d 20 4e 65 75 72 6f | 70 73 79 63 68 69 61 74 |.. Neuro|psychiat|
|00005d30| 72 69 63 20 6d 61 6e 69 | 66 65 73 74 61 74 69 6f |ric mani|festatio|
|00005d40| 6e 73 20 6f 63 63 75 72 | 20 69 6e 20 61 62 6f 75 |ns occur| in abou|
|00005d50| 74 20 36 30 20 70 65 72 | 63 65 6e 74 20 6f 66 20 |t 60 per|cent of |
|00005d60| 48 49 56 2d 69 6e 66 65 | 63 74 65 64 20 70 65 72 |HIV-infe|cted per|
|00005d70| 73 6f 6e 73 2e 20 49 74 | 20 69 73 20 6e 6f 77 20 |sons. It| is now |
|00005d80| 77 65 6c 6c 20 65 73 74 | 61 62 6c 69 73 68 65 64 |well est|ablished|
|00005d90| 20 74 68 61 74 20 48 49 | 56 20 63 61 6e 20 65 78 | that HI|V can ex|
|00005da0| 69 73 74 20 61 6e 64 20 | 70 72 6f 6c 69 66 65 72 |ist and |prolifer|
|00005db0| 61 74 65 20 77 69 74 68 | 69 6e 20 74 68 65 20 62 |ate with|in the b|
|00005dc0| 72 61 69 6e 2c 20 73 70 | 69 6e 61 6c 20 63 6f 72 |rain, sp|inal cor|
|00005dd0| 64 2c 20 61 6e 64 20 70 | 65 72 69 70 68 65 72 61 |d, and p|eriphera|
|00005de0| 6c 20 6e 65 72 76 65 73 | 2e 20 54 68 69 73 20 72 |l nerves|. This r|
|00005df0| 65 73 75 6c 74 73 20 69 | 6e 20 61 20 62 72 6f 61 |esults i|n a broa|
|00005e00| 64 20 72 61 6e 67 65 20 | 6f 66 20 73 79 6d 70 74 |d range |of sympt|
|00005e10| 6f 6d 73 2c 20 69 6e 63 | 6c 75 64 69 6e 67 20 6d |oms, inc|luding m|
|00005e20| 65 6e 69 6e 67 6f 65 6e | 63 65 70 68 61 6c 69 74 |eningoen|cephalit|
|00005e30| 69 73 2e 20 28 73 65 65 | 20 45 4e 43 45 50 48 41 |is. (see| ENCEPHA|
|00005e40| 4c 49 54 49 53 29 20 61 | 6e 64 20 44 45 4d 45 4e |LITIS) a|nd DEMEN|
|00005e50| 54 49 41 2e 20 45 76 69 | 64 65 6e 63 65 20 74 68 |TIA. Evi|dence th|
|00005e60| 75 73 20 66 61 72 20 69 | 6e 64 69 63 61 74 65 73 |us far i|ndicates|
|00005e70| 20 74 68 61 74 20 63 69 | 72 63 75 6c 61 74 69 6e | that ci|rculatin|
|00005e80| 67 20 48 49 56 2d 69 6e | 66 6c 65 63 74 65 64 20 |g HIV-in|flected |
|00005e90| 6d 6f 6e 6f 63 79 74 65 | 73 20 6d 61 79 20 62 65 |monocyte|s may be|
|00005ea0| 20 72 65 73 70 6f 6e 73 | 69 62 6c 65 20 66 6f 72 | respons|ible for|
|00005eb0| 20 74 68 65 20 69 6e 69 | 74 69 61 74 69 6f 6e 20 | the ini|tiation |
|00005ec0| 6f 66 20 69 6e 66 65 63 | 74 69 6f 6e 20 69 6e 20 |of infec|tion in |
|00005ed0| 74 68 65 20 62 72 61 69 | 6e 2c 20 77 69 74 68 20 |the brai|n, with |
|00005ee0| 6c 69 74 74 6c 65 20 65 | 76 69 64 65 6e 63 65 20 |little e|vidence |
|00005ef0| 74 6f 20 73 75 70 70 6f | 72 74 20 64 69 72 65 63 |to suppo|rt direc|
|00005f00| 74 20 69 6e 66 65 63 74 | 69 6f 6e 20 6f 66 20 6e |t infect|ion of n|
|00005f10| 65 75 72 6f 6e 20 74 69 | 73 73 75 65 20 62 79 20 |euron ti|ssue by |
|00005f20| 48 49 56 2e 20 42 6c 6f | 6f 64 2d 63 65 6c 6c 20 |HIV. Blo|od-cell |
|00005f30| 61 62 6e 6f 72 6d 61 6c | 69 74 69 65 73 20 6f 66 |abnormal|ities of|
|00005f40| 20 48 49 56 20 70 61 74 | 69 65 6e 74 73 20 69 6e | HIV pat|ients in|
|00005f50| 63 6c 75 64 65 20 41 4e | 45 4d 49 41 2c 20 72 65 |clude AN|EMIA, re|
|00005f60| 64 75 63 65 64 20 77 68 | 69 74 65 20 62 6c 6f 6f |duced wh|ite bloo|
|00005f70| 64 2d 63 65 6c 6c 20 63 | 6f 75 6e 74 73 2c 20 61 |d-cell c|ounts, a|
|00005f80| 6e 64 20 70 6c 61 74 65 | 6c 65 74 20 64 65 66 69 |nd plate|let defi|
|00005f90| 63 69 65 6e 63 69 65 73 | 2e 20 52 65 73 65 61 72 |ciencies|. Resear|
|00005fa0| 63 68 65 72 73 20 68 61 | 76 65 20 61 6c 73 6f 20 |chers ha|ve also |
|00005fb0| 62 65 65 6e 20 61 62 6c | 65 20 74 6f 20 73 68 6f |been abl|e to sho|
|00005fc0| 77 20 64 69 72 65 63 74 | 20 69 6e 66 65 63 74 69 |w direct| infecti|
|00005fd0| 6f 6e 20 6f 66 20 62 6f | 6e 65 2d 6d 61 72 72 6f |on of bo|ne-marro|
|00005fe0| 77 20 63 65 6c 6c 73 2d | 2d 74 68 65 20 70 72 65 |w cells-|-the pre|
|00005ff0| 63 75 72 73 6f 72 73 20 | 6f 66 20 63 69 72 63 75 |cursors |of circu|
|00006000| 6c 61 74 69 6e 67 20 62 | 6c 6f 6f 64 20 63 65 6c |lating b|lood cel|
|00006010| 6c 73 2d 2d 20 61 6e 64 | 20 74 68 65 20 70 72 6f |ls-- and| the pro|
|00006020| 6c 69 66 65 72 61 74 69 | 6f 6e 20 6f 66 20 74 68 |liferati|on of th|
|00006030| 65 20 76 69 72 75 73 20 | 77 69 74 68 69 6e 20 74 |e virus |within t|
|00006040| 68 65 73 65 20 63 65 6c | 6c 73 2e 20 54 68 75 73 |hese cel|ls. Thus|
|00006050| 20 62 6f 6e 65 20 6d 61 | 72 72 6f 77 20 6d 61 79 | bone ma|rrow may|
|00006060| 20 72 65 70 72 65 73 65 | 6e 74 20 61 6e 20 69 6d | represe|nt an im|
|00006070| 70 6f 72 74 61 6e 74 20 | 72 65 73 65 72 76 6f 69 |portant |reservoi|
|00006080| 72 20 6f 66 20 48 49 56 | 20 69 6e 20 61 6e 20 69 |r of HIV| in an i|
|00006090| 6e 66 65 63 74 65 64 20 | 70 65 72 73 6f 6e 20 61 |nfected |person a|
|000060a0| 6e 64 20 70 72 6f 76 69 | 64 65 20 61 20 70 6f 74 |nd provi|de a pot|
|000060b0| 65 6e 74 69 61 6c 20 6d | 65 63 68 61 6e 69 73 6d |ential m|echanism|
|000060c0| 20 66 6f 72 20 64 69 73 | 73 65 6d 69 6e 61 74 69 | for dis|seminati|
|000060d0| 6f 6e 20 6f 66 20 74 68 | 65 20 76 69 72 75 73 20 |on of th|e virus |
|000060e0| 74 68 72 6f 75 67 68 20 | 74 68 65 20 62 6f 64 79 |through |the body|
|000060f0| 2e 20 4f 74 68 65 72 20 | 48 49 56 2d 72 65 6c 61 |. Other |HIV-rela|
|00006100| 74 65 64 20 73 79 6e 64 | 72 6f 6d 65 73 20 69 6e |ted synd|romes in|
|00006110| 63 6c 75 64 65 20 6e 65 | 70 68 72 69 74 69 73 20 |clude ne|phritis |
|00006120| 28 73 65 65 20 4b 49 44 | 4e 45 59 20 44 49 53 45 |(see KID|NEY DISE|
|00006130| 41 53 45 29 2c 20 41 52 | 54 48 52 49 54 49 53 2c |ASE), AR|THRITIS,|
|00006140| 20 61 6e 64 20 6c 75 6e | 67 20 69 6e 66 6c 61 6d | and lun|g inflam|
|00006150| 6d 61 74 69 6f 6e 20 28 | 70 6e 65 75 6d 6f 6e 69 |mation (|pneumoni|
|00006160| 74 69 73 29 2e 20 43 65 | 72 74 61 69 6e 20 63 6f |tis). Ce|rtain co|
|00006170| 66 61 63 74 6f 72 73 20 | 61 70 70 65 61 72 20 74 |factors |appear t|
|00006180| 6f 20 70 6c 61 79 20 61 | 6e 20 69 6d 70 6f 72 74 |o play a|n import|
|00006190| 61 6e 74 20 72 6f 6c 65 | 20 69 6e 20 48 49 56 20 |ant role| in HIV |
|000061a0| 69 6e 66 65 63 74 69 6f | 6e 20 61 6e 64 20 41 49 |infectio|n and AI|
|000061b0| 44 53 20 62 79 20 69 6e | 63 72 65 61 73 69 6e 67 |DS by in|creasing|
|000061c0| 20 73 75 73 63 65 70 74 | 69 62 69 6c 69 74 79 20 | suscept|ibility |
|000061d0| 74 6f 20 69 6e 66 65 63 | 74 69 6f 6e 20 61 6e 64 |to infec|tion and|
|000061e0| 20 62 79 20 65 6e 68 61 | 6e 63 69 6e 67 20 76 69 | by enha|ncing vi|
|000061f0| 72 61 6c 2d 64 69 73 65 | 61 73 65 20 61 63 74 69 |ral-dise|ase acti|
|00006200| 76 69 74 79 2e 20 4f 74 | 68 65 72 20 73 65 78 75 |vity. Ot|her sexu|
|00006210| 61 6c 6c 79 20 74 72 61 | 6e 73 6d 69 74 74 65 64 |ally tra|nsmitted|
|00006220| 20 64 69 73 65 61 73 65 | 73 20 61 70 70 65 61 72 | disease|s appear|
|00006230| 20 74 6f 20 62 65 20 6f | 66 20 70 61 72 74 69 63 | to be o|f partic|
|00006240| 75 6c 61 72 20 73 69 67 | 6e 69 66 69 63 61 6e 63 |ular sig|nificanc|
|00006250| 65 2e 20 44 61 6d 61 67 | 65 20 74 6f 20 67 65 6e |e. Damag|e to gen|
|00006260| 69 74 61 6c 20 73 6b 69 | 6e 20 61 6e 64 20 6d 75 |ital ski|n and mu|
|00006270| 63 6f 75 73 20 6d 65 6d | 62 72 61 6e 65 73 20 6d |cous mem|branes m|
|00006280| 61 79 20 66 61 63 69 6c | 69 74 61 74 65 20 74 72 |ay facil|itate tr|
|00006290| 61 6e 73 6d 69 73 73 69 | 6f 6e 20 6f 66 20 74 68 |ansmissi|on of th|
|000062a0| 65 20 76 69 72 75 73 2e | 20 49 6e 20 61 64 64 69 |e virus.| In addi|
|000062b0| 74 69 6f 6e 2c 20 6c 61 | 62 6f 72 61 74 6f 72 79 |tion, la|boratory|
|000062c0| 20 73 74 75 64 69 65 73 | 20 73 68 6f 77 20 74 68 | studies| show th|
|000062d0| 61 74 20 63 65 72 74 61 | 69 6e 20 6d 69 63 72 6f |at certa|in micro|
|000062e0| 62 65 73 20 66 72 65 71 | 75 65 6e 74 6c 79 20 66 |bes freq|uently f|
|000062f0| 6f 75 6e 64 20 69 6e 20 | 41 49 44 53 20 70 61 74 |ound in |AIDS pat|
|00006300| 69 65 6e 74 73 2c 20 73 | 75 63 68 20 61 73 20 6d |ients, s|uch as m|
|00006310| 79 63 6f 70 6c 61 73 6d | 61 73 2c 20 65 6e 68 61 |ycoplasm|as, enha|
|00006320| 6e 63 65 20 74 68 65 20 | 74 72 61 6e 73 63 72 69 |nce the |transcri|
|00006330| 70 74 69 6f 6e 20 6f 66 | 20 48 49 56 2e 20 49 74 |ption of| HIV. It|
|00006340| 20 69 73 20 6c 69 6b 65 | 6c 79 20 74 68 61 74 20 | is like|ly that |
|00006350| 70 65 72 73 6f 6e 73 20 | 77 69 74 68 20 73 75 63 |persons |with suc|
|00006360| 68 20 61 20 63 6f 69 6e | 66 65 63 74 69 6f 6e 20 |h a coin|fection |
|00006370| 77 6f 75 6c 64 20 65 78 | 70 65 72 69 65 6e 63 65 |would ex|perience|
|00006380| 20 69 6e 63 72 65 61 73 | 65 64 20 48 49 56 20 72 | increas|ed HIV r|
|00006390| 65 70 6c 69 63 61 74 69 | 6f 6e 20 61 6e 64 20 61 |eplicati|on and a|
|000063a0| 6e 20 61 63 63 65 6c 65 | 72 61 74 65 64 20 64 65 |n accele|rated de|
|000063b0| 70 6c 65 74 69 6f 6e 20 | 6f 66 20 43 44 34 20 63 |pletion |of CD4 c|
|000063c0| 65 6c 6c 73 2c 20 6c 65 | 61 64 69 6e 67 20 74 6f |ells, le|ading to|
|000063d0| 20 61 6e 20 6f 76 65 72 | 61 6c 6c 20 70 72 6f 67 | an over|all prog|
|000063e0| 72 65 73 73 69 6f 6e 20 | 6f 66 20 64 69 73 65 61 |ression |of disea|
|000063f0| 73 65 2e 0d 00 1c 00 99 | 00 41 4e 45 4d 49 41 0d |se......|.ANEMIA.|
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